Event Abstract Back to Event Immunomodulatory properties of bifidobacteria strains Jirina Bartova1*, Alexandra Salakova2, Jan Drbohlav2, Petr Roubal2, Ondrej Sveda1 and Iva Lisova2 1 Institute of Clinical and Experimental Dental Medicine,General University Hospital and 1st Faculty of Medicine Charles University, Czechia 2 Dairy Research Institute, Czechia The use of bacteria in therapy has a long tradition. In the last years the number of clinical studies investigating bacteria in prevention or therapy of diseases has increased. The studies are based on the finding that interaction between microorganisms and the mucosal system of the intestine has important effects on development and function of immune system and on the health of the whole organism. The aim of the study was to analyze the immunomodulatory properties of probiotic bifidobacteria strains from the Collection of Dairy Microorganisms Laktoflora ®. The question was whether all strains react with blood mononuclear cells in the same way, or if there are differences between strains of the same species in cytokine stimulation and thus the strains may have a specific effect in the prevention and in the treatment of certain diseases. For this research was seleted 15 strains of the genus Bifidobacterium: B. animalis subsp. lactis, B. longum subsp. infantis, B. longum subsp. longum, B. dentium and Bifidobacterium sp. Method : Mononuclear cells isolated from peripheral blood of healthy persons were cultivated with selected Bifidobacterium strain for 3 days at 37o C and 5% CO2 . Pro-inflammatory and anti-inflammatory cytokines produced during stimulation was determined by Luminex quantitative multiplex method. Conclusion : It was found that different strains of bifidobacteria acting on the separated blood mononuclear cells stimulate cytokine production in individual manner. These characteristics of bifidobacteria strains could be used in the prevention and treatment of certain diseases. Acknowledgements P28/LF1/6 and RO0511. Keywords: Bifidobacterium, Immunomodulatory effect, cytokine production, mononuclear cells, Luminex Conference: 15th International Congress of Immunology (ICI), Milan, Italy, 22 Aug - 27 Aug, 2013. Presentation Type: Abstract Topic: Adaptive Immunity Citation: Bartova J, Salakova A, Drbohlav J, Roubal P, Sveda O and Lisova I (2013). Immunomodulatory properties of bifidobacteria strains. Front. Immunol. Conference Abstract: 15th International Congress of Immunology (ICI). doi: 10.3389/conf.fimmu.2013.02.00225 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 13 Mar 2013; Published Online: 22 Aug 2013. * Correspondence: Dr. Jirina Bartova, Institute of Clinical and Experimental Dental Medicine,General University Hospital and 1st Faculty of Medicine Charles University, Prague, Czechia, jirina.bartova@post.cz Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Jirina Bartova Alexandra Salakova Jan Drbohlav Petr Roubal Ondrej Sveda Iva Lisova Google Jirina Bartova Alexandra Salakova Jan Drbohlav Petr Roubal Ondrej Sveda Iva Lisova Google Scholar Jirina Bartova Alexandra Salakova Jan Drbohlav Petr Roubal Ondrej Sveda Iva Lisova PubMed Jirina Bartova Alexandra Salakova Jan Drbohlav Petr Roubal Ondrej Sveda Iva Lisova Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.